Dr. Nezami is an inventor and innovator and has designed a patented novel method of treating patients with advanced cancer, called Modified Multi Molecular Targeted Epigenetic Therapy (MTET). With this method, during the last 7 years, he has successfully treated many patients, mostly with advanced stage four cancer who had failed all other conventional methods. National Cancer Institute and all their related oncology consultants have confirmed this method of treating patients with cancer as novel and effective. Several cancer institutions, including MD Anderson cancer center and private oncology centers have already started investigating his method in either preclinical or clinical settings, showing "extra ordinary" results.
Dr. Nezami has served as principal investigator by National Institute of Health ( NIH); for TACT trial and is currently involved both in research and publications( as coauthor) with National Cancer Institute (NCI) in the best case series of complimentary and alternative cancer therapies.
He also functions as speaker and medical consultant for Caris Life Sciences ( Caris Oncology Laboratory) and provides scientific expert review at Journal of Cancer Therapy ( JCT), British Journal of Medicine and Medical Research, ( BJM) as well as serving as editorial board and peer review expert in multidisciplinary scientific journals such as Biology and Medicine, Science International, Journal of Advances in Medical and Pharmaceutical Sciences, Cancer Studies, Asian Journal of Medicine and Health, International journal of cancer and tumor, Biology and Medicine, Archivum Immunologiae Et Therapiae Experimentalis,...
Due to his expertise in the area of epigenetic science and oncology , he has recently been honored to serve as the organizer and/or chair for several oncology conferences, such as ICOR ( International conference on Oncology and Radiology), key note speaker and board member for several international oncology conferences.( ex. Radiation oncology and anti cancer therapy, International Conference on Nuclear Medicine and radiation therapy,...)
His main area of interest are integrative oncology and epigenetics. He currently teaches and consults other physicians and oncologists and is extensively involved in research and pursuing clinical trials in this field.
1. M.A Nezami,M.D., Mirshemirani, M., M D
“Retrospective study of 50 Hospitalized children with Nephroblastoma/ Wilm’s Tumor”
Clinical research, medical dissertation, April 1996
2. Davidson, G.C., Collins, L., Nezami, M.A. & Dequattro, V.L.
“Psychological correlates of heart’s structural variation.”
Poster presented at the society of behavioral science meeting, San Diego, California 1993
3. Nezami E., Davison, GC, Nezami, M.A. & Collins L.
“Hostility in relation to cardiovascular reactivity”
University of Southern California, Paper published in International Journal of Psychology, and presented in 26th international congress of psychology, Montreal, Canada, p. 127, 1996
4. Jadvar H, Xu A, Tumeh P, Pollock J, Nezami M.A., Conti PS
" Surveillance and management of lymphoma with serial FDG PET-CT",
Proc RSNA 91st Scientific Assembly & Ann Meeting, Chicago, IL, p. 673; 2005
5. M. A. Nezami, M.D, Victoria Kubal MS, BCBA, John Monteleone M.D., MPH Davin Young Clarke M.A., “Effects of Exercise Prescription and Nutrition Counseling on Patients at Risk for Cardiovascular Disease”Invited presenter, 3rd annual colloquium
University of California, San Francisco, (UCSF), 2007
6. J. Monteleone, MD, MPH, M.A. Nezami M.D., Mimi-Mott Smith FNP-MPH
“Changing Behavior using personalized exercise and nutrition prescriptions for patients at cardiovascular risk”
Society of Teachers in Family Medicine (STFM), 16th annual meeting, published STFM 16th annual journal, p 63, Chicago, 2007
7. M. Nezami, MD
” Improved symptoms of multiple sclerosis in response to nutritional therapy: an integrative approach to neurodegenerative disorders, a case report”
Integrative Medicine, A Clinician’s Journal ( IMCJ), Sept, 2011
8. M. Nezami MD
Tumor board presentation "Breast cancer complete remission using combination therapy, chemotherapy with epigenetic treatments, A case report" March, 2012, CRMC, Clovis, California
9. M. Nezami MD
MultiTargeted Epigenetic therapies, MTET
Invited presenter and candidate for partnership opportunities
Lymphoma and Leukemia Society (LLS), San Francisco, 2012
10. M.Nezami MD, S.Hager DO, D. Stobbe MD,
Multitargeted Epigenetic Therapy ( MTET) and it's rationale in an integrative approach
Institute for Research ( IRB) in Bio medicine, Barcelona International Conference on Epigenetics and Cancer, Barcelona, Spain, November, 2013
11. M.Nezami MD, S.Hager DO, D. Stobbe MD
Multitargeted Epigenetic Therapy ( MTET)
Molecular Med Tri-conference,( ex, human genome project and sequencing), February 10-12, 2014, San Francisco, CA
12. M.Nezami MD, S Hager, Do
"Surrogate markers of survival , a case review for an antiangiogenic therapy in cancer"
Pancreatic Cancer Innovations in research and treatment
American Association for Cancer Research ( AARC), May 18-21, 2014 New Orleans, Louisiana
13. M.Nezami MD, S Hager, Do, A. Gouldsimon MD
"Surrogate Markers for survival, a case review for an antiangiogenic therapy in cancer"
World Pharmaceutical Congress, Trackling Translational Challenges, May 21-23, 2014, Boston, Massachusetts
14. M.Nezami MD, Steve Hager DO, A. Gouldsimon MD
"Surrogate Markers of survival, a case review for an antiangiogenic therapy in cancer"
World Molecular Imaging Society and World Molecular Imaging Congress( WMIC)
Korea, September 2014
15. LEANNA J. STANDISH, LISE N. ALSCHULER, MORGAN WEAVER AND M. NEZAMI MD
Weil's Integrative Oncology Textbook, second edition,
Botanical and Mycological Medicine in Integrative Oncology
Integrative Oncology, Donald Abrams, Andrew Weil, Sep 2014
16. M.Nezami MD, Aron Gould Simon MD,
" Biological translational tools to predict clinical outcome in advanced cancer”
Molecular Med Tri-cone 2015, San Francisco, February 2015( human genome project and sequencing)
17. M. Nezami MD, J. Garner, Aron Gouldsimon, MD,
"Epigenetic regulation of angiogenesis", A review of 100 cases of advanced cancer"
Translational epigenetics, Festival of Genomics, Boston, June 23, 2015
18. M. Nezami MD, Daniel Stobe MD, Aron Gouldsimon, MD
"Translational epigenetics in lung cancer, A case review of multitargeted epigenetic therapy ( MTET)",
16th annual international lung cancer congress, Huntington Beach, CA July, 2015
19. Nezami MA, Gouldsimon A
" Heterogenous Approach for Heterogenous disease, Heterogeneity in cancer genomics and epigenetic approach", Cancer Science, vol 1,1, August 2015
20. M.Nezami MD, " Epigenetic regulation of hypoxia, Genomic Bioinformatics",
Europe Society of Bio Banking ( ESBB), London, Oct 1st, 2015
21. M. Nezami MD
"Biological interventions to interfere microenvironmental seduction by tumor cells"
Symposia on Cancer Research, Emerging concepts in host response to cancer, MD Anderson Cancer center, Houston, TX, October 8-9, 2015
22. M.Nezami MD, Steve Hager DO
" Prognostic surrogate makers for survival in pancreatic cancer, a case series for a novel antiangiogenic therapy( Multitargeted epigenetic therapy( MTET)
French Association for Pancreatic Cancer Research ( AFRCP), Pancreatic Cancer Symposium, Marcielle, France, October 28-30
23. M. Nezami MD, Steve Hager DO, Richard Lanman MD
" Impact of Multitargeted Epigenetic therapy ( MTET), a series of 100 consecutive advanced solid tumor cancers"
AACR- NCI EORTC Molecular Targets and Cancer Therapeutics Conference, Nov 5-9, 2015, Boston, Massachusetts
24. M. Nezami MD, Steve Hager DO
“Heterogenous approach for heterogenous disease, heterogeneity in cancer genomics and epigenetic approach”
AACR- NCI EORTC Molecular Targets and Cancer Therapeutics Conference, Nov 5-9, 2015, Boston, Massachusetts
25. M.Nezami MD, Aron Gouldsimon MD
" Application of multitargeted Epigenetic therapy and review of case series in recurrent advanced Non small Cell Lung Cancer, Heterogenous approach for heterogenous disease, Heterogeneity in cancer genomics and epigenetic approach"
Cancer Science, open access, scient online, Vol. 1, http://scientonline.org/open-access/heterogenous-approach-for-heterogenous-disease-heterogeneity-in-cancer-genomics-and-epigenetic-approach.pdf
26. M. Nezami MD, Jessica garner PA, Megan Elam
" Epigenetic therapies, Immune therapies and Anti angiogenic therapies, The Triad of Oncology"
Angiogenesis, The cause or effect?"
Journal of Precision Medicine, November 2015, Page 43
27. M. Nezami MD, Steve Hager DO, Jessica Garner PA,
" Epigenetic Regulation of heterogeneity in solid tumors, A case series for a novel epigenetic therapy"
Society of Integrative Oncology ( SIO), Integrative Innovations, Nov 12-14, 2015, Boston, Massachusetts
28. M.Nezami MD, Daniel Stobe MD, Aron Gould Simon MD
"Prognostic surrogate markers for survival, a case series for a novel antiangiogenic therapy( Multitargeted Epigenetic Therapies/ MTET)" Abstract 73
Society of Integrative Oncology( SIO), November 14-16, 2015, Boston, Massachusetts
29. M. Nezami MD
" Epigenetic regulation of hypoxia and heterogeneity in cancer"8th Euro Global Summit on Cancer Therapy, November 3th-5th, 2015, Valencia, Spain
30. M. Nezami MD
" Multitargeted Epigenetic therapy and it's application in a case series of Gastric Cancer"
2nd International Gastrointestinal Cancer Congress ( IGCC), October 14-16th, Shahid Beheshti University, Comprehensive Cancer Center, Tehran, Iran
31. Nezami M, Hager S, Garner, J
" Epidermomesenchymal (Transition( EMT) and Anti EMT Strategies in Cancer", Journal of Cancer therapy (JCT), Vol 6, No 11, November 2015, Paper ID: 890225
32. M.Nezami MD
"Epigenetic regulation of Hypoxia, a case series for multitargeted epigenetic therapy"4th Cancer Epigenetic Conference, Global Technology Community ( GTC), November 16-17th, San Francisco, CA
33. M.Nezami MD, A Gouldsimon, D. Stobe
" Epigenetic regulation of Hypoxia and heterogeneity", ESMO Journal , Annals of Oncology, Submission ID:#495ESMO
Asia 2015 Congress, December 18-21, Singapore
34. M. Nezami MD
“Chemoprevention and epigenetic multitargeted approach” , 2016 Cancer survivorship Symposium: Advancing Care and Research, Abstract Submission ID:156951 (Abstract Number for Online Publication: e297)
35.M. Nezami MD, Aroun Gouldsimon MD, Jessica Garner
"Correlation of an EX VIVO model with clinical application of an epigenetic modifier, inhibiting tumor growth and metastasis, in resistant cholangiocarcinoma - A case study" ,
Journal of Cancer Therapy, Vol 7, No.1, Jan 2016
36. M.Nezami MD
"Chemoprevention and Epigenetic Multitargeted Approach"
Dana-Farber Cancer Institute, Cancer Survivorship Symposium: Advancing Care and Research
Journal of Clinical Oncology 34, 2016 ( Suppl 3S, Abstr e297)
37. M.Nezami MD
"Multitargeted Epigenetic therapy and it's application in a case series of advanced Gastric Cancer"
The 2nd International Conference on Oncology and Therapy (COT 2016)
March 2 - 4, 2016 in Beijing, China.
38. M. Nezami MD, Aroun GouldSimon MD
"Biological interventions to interfere microenvironmental seduction by tumor cells, a breakthrough strategy in clinical oncology to inhibit angiogenesis and metastasis"
Molecular Medicine TRI-CON 2016 , March 6 -11, 2016, San Francisco, CA
39.M.A.Nezami MD, Steve Hager Do, Jessica Garner PA
" Preliminary Findings on Multi-Targeted Epigenetic Therapy in Modifying Telomerase Activity"
Journal of Cancer Science( Scient Open Access Journal), March 16, 2016
40. M.Nezami MD
" Invitro and invivo proof of concept for an effective antineoplastic combination of novel anti HIF therapy in pancreatic cancer"
American Association for Cancer Research ( AACR), Pancreatic Cancer, Advances in Science and Clinical Care
May 12-15, Orlando, Florida
41. M.Nezami MD, S. Hager, DO J. Garner
"The Role of Telomeres in Cancer Development and Progression, and the Double Edge Sword Effect with Tamoxifen"
Biology and Medicine ( Biol Med 2016, 8:3)
42. M. Nezami MD, Steven Hager DO, Jessica Garner
"Preliminary Findings on Multi-Targeted Epigenetic Therapy (MTET) in Modifying Telomerase Activity"
- Cancer Science; Open Access, Scient access, published March, 2016
43. M. Nezami MD, Steven Hager DO, Jessica Garner
"Epigenetic Tumor Response to Hypoxia: An Epimutation Pattern and a Method of Multi-Targeted Epigenetic Therapy (MTET)" - Journal of Cancer Therapy, Vol 7, No 4, Apr 13, 2016, DOI: 10.4236/jct.2016.74027
44. M. Nezami MD
Peer review expert, British Journal of Medicine and Medical Research
" Tumor markers in head and neck neoplasm: an overview"
45. Peer review expert, Science Domain International, Asian Journal of Medicine and Health
" Superficial Angiomyxoma of right gluteal region- A rare case report"
46. Peer review expert, Science Domain International,Journal of Advances in Medical and Pharmaceutical Sciences
" Effect of Hypoxia-inducible factor-1 and 2 on tumor growth"
47. Peer review expert, Science Domain, Journal of cancer and tumor international," The interest of serum alkaline phosphatase in the confirmation of diagnosis for tumors in children and adolescents" Ms_JCTI_2993
48. Peer Review Expert, Biology and Medicine, Medical Sciences 17-134
"Association between serum Trans fatty acids concentrations and leucocyte telomere length in US adults" Feb, 2017
49. Peer review expert, Biology and Medicine, Medical Sciences 17-285
" Long Non-coding RNA Biomarker for Human Laryngeal Squamous Cell Carcinoma Prognosis", March 2017
50. Peer Review expert, Journal of Advancements in Medicine and medical research, Science Domain, Apr, 2018 "“Space Occupying Lesions (SOL) of brain - Clinical manifestation with subtle neurological symptoms in Emergency Department.”
51. M.Nezami MD
"Epigenetic regulation of hypoxia: Modifying metastasis by regulating epigenome- A Case review of multi targeted epigenetic therapy (MTET) and its application in Stage IV Renal Cell Carcinoma
( submitted to) International Conference on Oncology and Radiology( ICOR), Dubai, UAE
October 27-29, 2016
52. M.Nezami MD
( Key note speaker and organizing committee member)
"Epigenetic therapies and the use of multitargeted approach, a new concept in cancer therapeutics"
Journal of Cancer Science and Therapy, /WST.aspx
14th world anti cancer therapy convention
Dubai, UAE, Nov 21-22, 2016
53. M.Nezami MD
" Biological interventions to interfere microenvironmental and endocrine machinery in cancer" Application of endocrine manipulation in advanced cancer
Journal of Cancer Science and Therapy, November 21-23, 2016,
54. M.Nezami MD, Jessica Garner
"Role of antiangiogenic therapy in prevention of recurrence in hormonal positive breast cancer, a secondary prevention strategy and method of therapy", Journal of Cancer therapy, 6.2017, 8/546.552
55. M. Nezami MD, "Multi targeted Epigenetic therapy and hypoxia response elements, A turning point in radiation oncology"
2nd International conference on Nuclear Medicine and Radiation Therapy, July 27-28, 2017, Rome, Italy
56. M.Nezami MD
" Biological modulation of PARP inhibition in triple negative breast cancer: A case report of combinational approach implementing histone deacetylase inhibition with PARP inhibition in advanced breast cancer", 2017 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics conference, October 26-30, 2017 in Philadelphia, Pennsylvania
57. M.Nezami MD, “ From Innovation to commercialization”, Biotechnology Show Case, san Francisco, Januray 7-10, 2018
58. M. Nezami MD
“Molecular profiling in cancer and correlation of liquid biopsies with clinical outcome”
Invited presenter, Bastyr University, March 2018
59. Julie Taguchi, Christopher Duma, M. A. Nezami
"A Novel Combined Approach for Metastatic Breast Cancer with Dural and Leptomeningeal Disease with an Impressive Clinical Outcome: A Case Study", JCT, March 2018
60. M.Nezami MD
" Landscape of BRCA1 and BRCA2 Germline, somatic and reversion alerations detectable of cell free DNA testing among patients with metastatic breast, ovarian, pancreatic, or prostate cancer,"
Aditya Bardia, ,...M.Nezami MD, Sandip Patel, Benedito Carneiro, Grace Wang, Alice Fan,..Massimo Christo Fanilli
Harvard Medical School Boston, Pacific Medical Center of Hope, University of California, SD, Stanford University
61. M.Nezami MD, Christopher Duma MD "Proof of Concept in a Case Study of Glioblastoma Multiforme Successfully Treated with IV Quercetin in Combination with Leading Edge Gamma Knife and Standard Treatments", Journal of Cancer Therapy ( JCT), Volume 9, No. 6, June 2018, 10.4236/jct.2018.96043
62. 25. M.Nezami , Steve Hager, Julie Taguchi, "Biological Modulation of PARP Inhibition in Triple Negative Breast Cancer, a Combinational Approach Implementing Multitargeted Epigenetic Therapy (MTET) with PARP Inhibition, in Advanced Breast Cancer: A Case Study". JCT, Sept 2018, ISSN 2151-1942
63. M.Nezami, Steve Hager " Evidence Based Medicine, in Precision Oncology, JCT, Sept 2018, Vol9, Number 9, 679-805, Sept 2018, Journal of Cancer Therapy, http://www.scirp.org/journal/
Find out what goes on in a consultation to become a patient.
1996: Medical Dissertation, Data collection and management “Evaluating 50 hospitalized Children with Nephroblastoma”Tehran Children hospital, Iran
1996: Research Investigator “The effect of hostility and cardiovascular reactivity”,University of Southern California, Department of preventive medicine (refer to presentations)
2004-2005: Research Investigator “Surveillance and management of lymphoma with serial FDG PET-CT”
University of Southern California, Department of Radiology and nuclear Medicine (refer to publication )
2006-2007: Principal Investigator Protocol development and Data analysis “Effectiveness of exercise prescription on resting heart rate in patients with risk factors for cardiovascular disease” (refer to
presentations) University of California, San Francisco, (UCSF-fresno)
2009-2010: Principal Investigator Trial to Assess Chelation Therapy National Institute of Health (NIH)
2011-PRESENT: Data collection for submission as best case series in complimentary and alternative medicine
Office of Cancer Complementary and Alternative Medicine National Cancer Institute (NCI)
2013: Co-authorBotanical and Mycological Medicine in Integrative Oncology Integrative Oncology (Weil Integrative Medicine Textbook), Donald Abrams, Andrew Weil, 2013
2013: Presenter Multi targeted Epigenetic Therapies ( MTET)) and it's rationale in an integrative approach
Institute for Research ( IRB) in Bio medicine, Barcelona International Conference on Epigenetics and Cancer, November, 2013
Multi targeted Epigenetic Therapies ( MTET), a case review of outcomes in patients with advanced cancer
Molecular Med Tri-cone 2014, February 10-12, 2014 (ex, human genome project and sequencing)
2014: Presenter, Prognostic surrogate markers of survival , a case review for a novel antiangiogenic therapy American Association for Cancer Research ( AARC) Pancreatic Cancer Innovations in research and treatment May 18-21, 2014 New Orleans, Louisiana
2014: Presenter, Prognostic surrogate markers for survival, a case review for a novel antiangiogenic therapy World Pharmaceutical Congress, Tracking Translational Challenges, May 21-23, 2014,
2016: Speaker and Medical consultant Caris Life Sciences ( Caris Oncology Laboratory)
2016: Peer review expert Journal of Cancer Therapy
(JCT) British Journal of Medicine and Medical Research. (BJM) Journal of cancer and tumor international
2016: Organizing committee member International conference on Radiation Oncology ad Anti cancer therapy, Dubai
2017: Editorial BoardCancer Studies
Meet our amazing staff from both centers in Fresno and Newport Beach, California.
Dr. Nezami is a graduate of USC and UCSF residencies. He has functioned as a faculty during his training as well as invited presenter at society of teachers in Family medicine. He has been in practice for 20 years and currently is the president of Pacific Medical Center of Hope in California. He is promoting research in conventional and integrative oncology, in cutting edge.
Dr Nezami serves as national and international speaker in oncology and epigenetic science. He has been involved in many research projects and publications, presentations ( including Society of integrative oncology( SIO), American Association for Cancer Research ( AACR), Molecular Medicine Triconference, World Molecular Imaging( WMI), and World Pharmaceutical Congress, NCI-AACR, .... Author, Integrative Medicine, A Clinician Journal, as well as author and coauthor in oncology literature. (Surveillance in lymphoma, published 2006, Cancer Science 2015, JCT 2015, 2016, Precision medicine,.....).
He has co authored Weil’s " Textbook for Integrative Oncology" in 2014.
B I O G R A P H Y
NEW!!! A bi-weekly journal from Dr.Nezami.
With knowledge there is long life. You are the messengers to other people who have cancer or other chronic diseases, and they're suffering because they don't know. So if you know that there is another treatment that works as good or even beyond the standard treatment, I would encourage you to save their life because that's why I'm here too."
- M.A. Nezami, MD.
2003-present: American Medical Association (AMA)
2004-present: Medical Board of California
2006-present: American Academy of Family Physicians (AAFP)
2006: American Society of Teachers in Family Medicine (STFM)
2006-present: UCSF Medical Alumni Association
2007: Fresno-Madera Medical Society (FMMS)
2007: California Academy of Family Physicians (CAFP)
2007: American Academy of Home Care Physicians
2008:The International Hormone Society
2008:The American Association of Aesthetic Medicine & Surgery
2008-present: American College for Advancement in Medicine (ACAM)
2008: National Institute for Complementary and Alternative Medicine (NCAM)
2010: Integrative Oncology Fellowship Program, A4M
2011: Best Answers for Cancer Foundation
2011: International Organization for Integrative Cancer Physicians (IOICP)
2011: American Academy of Physicians and Surgeons (AAPS)
2011: Society of Integrative Oncology (SIO)
2012: International Organization of Integrative Physicians (IOICP)
2012: Association of diving and hyperbaric professionals
2012: The international hyperbaric medical association (IHMS)
2014: American Association for Cancer Research ( AARC)